Electronic – How to generate different noise in LTspice from run to run

Proteus VSM (Virtual System Modeling) does not operate in real-time, at least not on even very high end desktop computers. The simulation is very processor-intensive, as you would notice if you brought up Windows Task Manager while the simulation is running. Depending on your computer's capabilities and the number of active simulation elements in your design, the actual simulation speed varies widely.

One way to estimate how much slower than real-time the simulator works, is to incorporate a loop (not a timer ISR) in your simulated microcontroller code, that flips some GPIO once every so many counts. Let's say we set this period to be around a tenth of a second in real-time, by counting clock cycles of code.

So, if the simulation flips that bit once every 20 seconds, the simulation is running at 1/200th of real-time.

Add a couple of active simulation elements to the design, then run the simulation again and watch the bit-flipping, to see how much slower it gets.

That being said, there isn't actually any practical way to achieve true real-time simulation of any non-trivial Proteus design, with present-day consumer hardware. By throwing enough processing power at it, perhaps by overclocking your PC massively, real-time might be feasible, but I wouldn't hold my breath on it.

From what I understand, those problems are often solved with metaheuristics, like genetic algorithms: they have been successfully applied in solving engineering problems.

I don't know how well it would apply to your case, but antenna design has been done using genetic algorithms.