Postfix Spamassassin deferred queue massive error

I have been witnessing some massive problems with my Postfix email server, equipped with Dovecot, and spamassassin.

The log files show errors like below, and there are thousands of such lines in the logs.

Mar 13 14:21:48 centos postfix/qmgr[1908]: warning: 5ABBA1425BF: defer service failure
Mar 13 14:21:48 centos postfix/qmgr[1908]: 5ABBA1425BF: to=<alozano1@terra.es>, relay=none, delay=1929, delays=1706/223/0/0, dsn=4.3.0, status=deferred (mail transport unavailable)
Mar 13 14:21:48 centos postfix/qmgr[1908]: warning: 5ABBA1425BF: defer service failure
Mar 13 14:21:48 centos postfix/qmgr[1908]: 5ABBA1425BF: to=<aloupie@thetis.gr>, relay=none, delay=1929, delays=1706/223/0/0, dsn=4.3.0, status=deferred (mail transport unavailable)
Mar 13 14:21:48 centos postfix/qmgr[1908]: warning: 5ABBA1425BF: defer service failure
Mar 13 14:21:48 centos postfix/qmgr[1908]: 5ABBA1425BF: to=<alozanop@visteon.com>, relay=none, delay=1929, delays=1706/223/0/0, dsn=4.3.0, status=deferred (mail transport unavailable)
Mar 13 14:21:48 centos postfix/qmgr[1908]: warning: 5ABBA1425BF: defer service failure
Mar 13 14:21:48 centos postfix/qmgr[1908]: 5ABBA1425BF: to=<alowe@wset.com>, relay=none, delay=1929, delays=1706/223/0/0, dsn=4.3.0, status=deferred (mail transport unavailable)
Mar 13 14:21:48 centos postfix/qmgr[1908]: warning: 5ABBA1425BF: defer service failure
Mar 13 14:21:48 centos postfix/qmgr[1908]: 5ABBA1425BF: to=<alove@wtamu.edu>, relay=none, delay=1929, delays=1706/223/0/0, dsn=4.3.0, status=deferred (mail transport unavailable)
Mar 13 14:21:48 centos postfix/qmgr[1908]: warning: 5ABBA1425BF: defer service failure
Mar 13 14:21:48 centos postfix/qmgr[1908]: 5ABBA1425BF: to=<alouisjr12_10@yahoo.com>, relay=none, delay=1929, delays=1706/223/0/0, dsn=4.3.0, status=deferred (mail transport unavailable)

This is creating massive trouble with the email servers, as it is preventing me from sending any emails.

UPDATE
I managed to overcome the POstfix logs shown above by deleting the complete queue using postsuper -d ALL

But, now i need to overcome the issue with Spamassassin not getting connected.

Mar 13 15:09:49 centos spamc[2511]: connect to spamd on 127.0.0.1 failed, retrying (#2 of 3): Connection refused
Mar 13 15:09:50 centos spamc[2511]: connect to spamd on 127.0.0.1 failed, retrying (#3 of 3): Connection refused
Mar 13 15:09:51 centos spamc[2511]: connection attempt to spamd aborted after 3 retries

Any help with this is much appreciated, thanks in advance, let me know if you need anything and i will upload it for you to see