I don't quite understand the differences between the two besides the obvious price differences. What does each offer over the other?
RDIMM vs UDIMM – What is the Difference
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No, it is not compatible at all. If your motherboard doesn't support registered memory then you can't use it.
Would you buy a PC from 2009 in 2012? Just know and understand what you're getting...
The ML350 G5 is simply an old generation product (active from 2006-2009). The G6 is newer. Both have been eclipsed by more modern options. So you're talking about a major shift in processing architecture (going from Intel 5400-series to the 5500 and 5600 available in the G6).
The machines look nearly identical in tower form.
They're both relatively quiet. The ILO 2 technology is the same between the two servers. The G6 will have Hyperthreading, Turbo Boost, more RAM options and be a better virtualization platform overall. The RAID controller and storage subsystem is a bit better as well. Keep in mind that the tower servers are no longer HP's primary focus, so the ML350 did not have a G7 equivalent.
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Best Answer
Dell has a nice forum article about the differences. RDIMM is REGISTERED memory and UDIMM is UNREGISTERED memory.
This means a few things: UDIMM is limited to two DIMMs per memory channel and UDIMMs offer slightly better memory bandwidth for one DIMM per channel. However when using two or three DIMMs per channel, you will get better memory bandwidth with RDIMMs.