Recently I'm seeing GUID folder names pop up on the system drive of my Server 2008 R2 machine (example below). Does anyone have any idea as to what might be causing these? If you open the folder there's nothing only an empty amd64 folder within.
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I think it might be WSUS unpacking patches and failing to clean up properly after itself
EDIT 2014-11-24 Added screenshot of permissions
Best Answer
You're close--close enough that the folders might have been created as part of the Windows Update process. But Windows update itself didn't unpack the patches there--it always downloads to %windir%\SoftwareDistribution\Download.
These folders were created by Windows Installer. To quote from this MSDN article: