WSUS – Purge All Settings from Windows 2016 Domain

Update: I would have tried to use process monitor. And see if file/registry access fails around the time of the error. And if possible, compare the output to a server that doesn't fail.

**Before update:**Check ( and disable ):
anti-virus
anti-spyware

also check temp system environment variable.

If you're using Group Policy to configure your updates, you can query the registry for the Target Group and WSUS server values:

C:\> REG QUERY "HKLM\Software\Policies\Microsoft\Windows\WindowsUpdate"
  WUServer    REG_SZ    http://fcsd-sccm
  WUStatusServer    REG_SZ    http://fcsd-sccm
  TargetGroupEnabled    REG_DWORD    0x1
  TargetGroup    REG_SZ    Servers

Or just get the WUServer value alone:

C:> REG QUERY "HKLM\Software\Policies\Microsoft\Windows\WindowsUpdate" /v "WUServer"
  WUServer    REG_SZ    http://fcsd-sccm

If the WUServer value is not present, you're connecting to Microsoft.

The Powershell equivalent:

Get-ItemProperty HKLM:\Software\Policies\Microsoft\Windows\WindowsUpdate