[Edited 2021-10-16 to reflect latest best-practices for producing RFC4122-complaint UUIDs]

Most readers here will want to use the uuid module. It is well-tested and supported.

The crypto.randomUUID() function is an emerging standard that is supported in Node.js and an increasing number of browsers.

If neither of those work for you, there is this method (based on the original answer to this question):

function uuidv4() {
  return ([1e7]+-1e3+-4e3+-8e3+-1e11).replace(/[018]/g, c =>
    (c ^ crypto.getRandomValues(new Uint8Array(1))[0] & 15 >> c / 4).toString(16)
  );
}

console.log(uuidv4());

Note: The use of any UUID generator that relies on Math.random() is strongly discouraged (including snippets featured in previous versions of this answer) for reasons best-explained here. TL;DR: Math.random()-based solutions do not provide good uniqueness guarantees.

Native deep cloning

It's called "structured cloning", works experimentally in Node 11 and later, and hopefully will land in browsers. See this answer for more details.

Fast cloning with data loss - JSON.parse/stringify

If you do not use Dates, functions, undefined, Infinity, RegExps, Maps, Sets, Blobs, FileLists, ImageDatas, sparse Arrays, Typed Arrays or other complex types within your object, a very simple one liner to deep clone an object is:

JSON.parse(JSON.stringify(object))

const a = {
  string: 'string',
  number: 123,
  bool: false,
  nul: null,
  date: new Date(),  // stringified
  undef: undefined,  // lost
  inf: Infinity,  // forced to 'null'
  re: /.*/,  // lost
}
console.log(a);
console.log(typeof a.date);  // Date object
const clone = JSON.parse(JSON.stringify(a));
console.log(clone);
console.log(typeof clone.date);  // result of .toISOString()

See Corban's answer for benchmarks.

Reliable cloning using a library

Since cloning objects is not trivial (complex types, circular references, function etc.), most major libraries provide function to clone objects. Don't reinvent the wheel - if you're already using a library, check if it has an object cloning function. For example,

• lodash - cloneDeep; can be imported separately via the lodash.clonedeep module and is probably your best choice if you're not already using a library that provides a deep cloning function
• AngularJS - angular.copy
• jQuery - jQuery.extend(true, { }, oldObject); .clone() only clones DOM elements
• just library - just-clone; Part of a library of zero-dependency npm modules that do just do one thing. Guilt-free utilities for every occasion.

ES6 (shallow copy)

For completeness, note that ES6 offers two shallow copy mechanisms: Object.assign() and the spread syntax. which copies values of all enumerable own properties from one object to another. For example:

var A1 = {a: "2"};
var A2 = Object.assign({}, A1);
var A3 = {...A1};  // Spread Syntax