Consider a web app in which a call to the app consists of PHP script running several MySQL queries, some of them memcached.
The PHP does not do very complex job. It is mainly serving the MySQL data with some formatting.
In the past it used to be recommended to put MySQL and the app engine (PHP/Apache) on separate boxes.
However, when the data can be divided horizontally (for example when there are ten different customers using the service and it is possible to divide the data per customer) and when Nginx +FastCGI is used instead of heavier Apache, doesn't it make sense to put Nginx Memcache and MySQL on the same box? Then when more customers come, add similar boxes?
Background: We are moving to Amazon Ec2. And a separate box for MySQL and app server means double EBS volumes (needed on app servers to keep the code persistent as it changes often). Also if something happens to the database box, more customers will fail.
Clarification: Currently the app is running with LAMP on a single server (before moving to EC2).
Best Answer
If your application architecture is already designed to support Nginx and MySQL on separate instances, you may want to host all your services on the same instance until you receive enough traffic that justifies the separation.
In general, creating new identical instances with the full stack (Nginx + Your Application + MySQL) will make your setup much more difficult to maintain. Think about taking backups, releasing application updates, patching the database engine, updating the database schema, generating reports on all your clients, etc. If you opt for this method, you would really need to find some big advantages in order to offset all the disadvantages.