Nginx works as a front end server, which in this case proxies the requests to a node.js server. Therefore you need to setup an nginx config file for node.

This is what I have done in my Ubuntu box:

Create the file yourdomain.com at /etc/nginx/sites-available/:

vim /etc/nginx/sites-available/yourdomain.com

In it you should have something like:

# the IP(s) on which your node server is running. I chose port 3000.
upstream app_yourdomain {
    server 127.0.0.1:3000;
    keepalive 8;
}

# the nginx server instance
server {
    listen 80;
    listen [::]:80;
    server_name yourdomain.com www.yourdomain.com;
    access_log /var/log/nginx/yourdomain.com.log;

    # pass the request to the node.js server with the correct headers
    # and much more can be added, see nginx config options
    location / {
      proxy_set_header X-Real-IP $remote_addr;
      proxy_set_header X-Forwarded-For $proxy_add_x_forwarded_for;
      proxy_set_header Host $http_host;
      proxy_set_header X-NginX-Proxy true;

      proxy_pass http://app_yourdomain/;
      proxy_redirect off;
    }
 }

If you want nginx (>= 1.3.13) to handle websocket requests as well, add the following lines in the location / section:

proxy_http_version 1.1;
proxy_set_header Upgrade $http_upgrade;
proxy_set_header Connection "upgrade";

Once you have this setup you must enable the site defined in the config file above:

cd /etc/nginx/sites-enabled/ 
ln -s /etc/nginx/sites-available/yourdomain.com yourdomain.com

Create your node server app at /var/www/yourdomain/app.js and run it at localhost:3000

var http = require('http');

http.createServer(function (req, res) {
    res.writeHead(200, {'Content-Type': 'text/plain'});
    res.end('Hello World\n');
}).listen(3000, "127.0.0.1");
console.log('Server running at http://127.0.0.1:3000/');

Test for syntax mistakes:

nginx -t

Restart nginx:

sudo /etc/init.d/nginx restart

Lastly start the node server:

cd /var/www/yourdomain/ && node app.js

Now you should see "Hello World" at yourdomain.com

One last note with regards to starting the node server: you should use some kind of monitoring system for the node daemon. There is an awesome tutorial on node with upstart and monit.

Edit:

If you are using Docker-for-mac or Docker-for-Windows 18.03+, just connect to your mysql service using the host host.docker.internal (instead of the 127.0.0.1 in your connection string).

If you are using Docker-for-Linux 20.10.0+, you can also use the host host.docker.internal if you started your Docker container with the --add-host host.docker.internal:host-gateway option.

Otherwise, read below

TLDR

Use --network="host" in your docker run command, then 127.0.0.1 in your docker container will point to your docker host.

Note: This mode only works on Docker for Linux, per the documentation.

Note on docker container networking modes

Docker offers different networking modes when running containers. Depending on the mode you choose you would connect to your MySQL database running on the docker host differently.

docker run --network="bridge" (default)

Docker creates a bridge named docker0 by default. Both the docker host and the docker containers have an IP address on that bridge.

on the Docker host, type sudo ip addr show docker0 you will have an output looking like:

[vagrant@docker:~] $ sudo ip addr show docker0
4: docker0: <BROADCAST,MULTICAST,UP,LOWER_UP> mtu 1500 qdisc noqueue state UP group default
    link/ether 56:84:7a:fe:97:99 brd ff:ff:ff:ff:ff:ff
    inet 172.17.42.1/16 scope global docker0
       valid_lft forever preferred_lft forever
    inet6 fe80::5484:7aff:fefe:9799/64 scope link
       valid_lft forever preferred_lft forever

So here my docker host has the IP address 172.17.42.1 on the docker0 network interface.

Now start a new container and get a shell on it: docker run --rm -it ubuntu:trusty bash and within the container type ip addr show eth0 to discover how its main network interface is set up:

root@e77f6a1b3740:/# ip addr show eth0
863: eth0: <BROADCAST,UP,LOWER_UP> mtu 1500 qdisc pfifo_fast state UP group default qlen 1000
    link/ether 66:32:13:f0:f1:e3 brd ff:ff:ff:ff:ff:ff
    inet 172.17.1.192/16 scope global eth0
       valid_lft forever preferred_lft forever
    inet6 fe80::6432:13ff:fef0:f1e3/64 scope link
       valid_lft forever preferred_lft forever

Here my container has the IP address 172.17.1.192. Now look at the routing table:

root@e77f6a1b3740:/# route
Kernel IP routing table
Destination     Gateway         Genmask         Flags Metric Ref    Use Iface
default         172.17.42.1     0.0.0.0         UG    0      0        0 eth0
172.17.0.0      *               255.255.0.0     U     0      0        0 eth0

So the IP Address of the docker host 172.17.42.1 is set as the default route and is accessible from your container.

root@e77f6a1b3740:/# ping 172.17.42.1
PING 172.17.42.1 (172.17.42.1) 56(84) bytes of data.
64 bytes from 172.17.42.1: icmp_seq=1 ttl=64 time=0.070 ms
64 bytes from 172.17.42.1: icmp_seq=2 ttl=64 time=0.201 ms
64 bytes from 172.17.42.1: icmp_seq=3 ttl=64 time=0.116 ms

docker run --network="host"

Alternatively you can run a docker container with network settings set to host. Such a container will share the network stack with the docker host and from the container point of view, localhost (or 127.0.0.1) will refer to the docker host.

Be aware that any port opened in your docker container would be opened on the docker host. And this without requiring the -p or -P docker run option.

IP config on my docker host:

[vagrant@docker:~] $ ip addr show eth0
2: eth0: <BROADCAST,MULTICAST,UP,LOWER_UP> mtu 1500 qdisc pfifo_fast state UP group default qlen 1000
    link/ether 08:00:27:98:dc:aa brd ff:ff:ff:ff:ff:ff
    inet 10.0.2.15/24 brd 10.0.2.255 scope global eth0
       valid_lft forever preferred_lft forever
    inet6 fe80::a00:27ff:fe98:dcaa/64 scope link
       valid_lft forever preferred_lft forever

and from a docker container in host mode:

[vagrant@docker:~] $ docker run --rm -it --network=host ubuntu:trusty ip addr show eth0
2: eth0: <BROADCAST,MULTICAST,UP,LOWER_UP> mtu 1500 qdisc pfifo_fast state UP group default qlen 1000
    link/ether 08:00:27:98:dc:aa brd ff:ff:ff:ff:ff:ff
    inet 10.0.2.15/24 brd 10.0.2.255 scope global eth0
       valid_lft forever preferred_lft forever
    inet6 fe80::a00:27ff:fe98:dcaa/64 scope link
       valid_lft forever preferred_lft forever

As you can see both the docker host and docker container share the exact same network interface and as such have the same IP address.

Connecting to MySQL from containers

bridge mode

To access MySQL running on the docker host from containers in bridge mode, you need to make sure the MySQL service is listening for connections on the 172.17.42.1 IP address.

To do so, make sure you have either bind-address = 172.17.42.1 or bind-address = 0.0.0.0 in your MySQL config file (my.cnf).

If you need to set an environment variable with the IP address of the gateway, you can run the following code in a container :

export DOCKER_HOST_IP=$(route -n | awk '/UG[ \t]/{print $2}')

then in your application, use the DOCKER_HOST_IP environment variable to open the connection to MySQL.

Note: if you use bind-address = 0.0.0.0 your MySQL server will listen for connections on all network interfaces. That means your MySQL server could be reached from the Internet ; make sure to setup firewall rules accordingly.

Note 2: if you use bind-address = 172.17.42.1 your MySQL server won't listen for connections made to 127.0.0.1. Processes running on the docker host that would want to connect to MySQL would have to use the 172.17.42.1 IP address.

host mode

To access MySQL running on the docker host from containers in host mode, you can keep bind-address = 127.0.0.1 in your MySQL configuration and all you need to do is to connect to 127.0.0.1 from your containers:

[vagrant@docker:~] $ docker run --rm -it --network=host mysql mysql -h 127.0.0.1 -uroot -p
Enter password:
Welcome to the MySQL monitor.  Commands end with ; or \g.
Your MySQL connection id is 36
Server version: 5.5.41-0ubuntu0.14.04.1 (Ubuntu)

Copyright (c) 2000, 2014, Oracle and/or its affiliates. All rights reserved.

Oracle is a registered trademark of Oracle Corporation and/or its affiliates. Other names may be trademarks of their respective owners.

Type 'help;' or '\h' for help. Type '\c' to clear the current input statement.

mysql>

note: Do use mysql -h 127.0.0.1 and not mysql -h localhost; otherwise the MySQL client would try to connect using a unix socket.