If you use Firefox, you can open about:config and edit the keyword.URL preference. Set its value to https://www.google.com/search?hl=en&ie=UTF-8&oe=UTF-8&btnG=Google+Search&q=-gaming -newgrounds -knowyourmeme. Don't forget the trailing space! This will cause URL bar search to apply the filters you specify.
Still in Firefox, you can create a bookmark to the URL https://www.google.com/search?hl=en&ie=UTF-8&oe=UTF-8&btnG=Google+Search&q=-gaming -newgrounds -knowyourmeme %s and assign a keyword to it (by right-clicking the bookmark and clicking Properties). Let's say you assign the g keyword. Now if you type g my search in the URL bar, you will perform a search on "my search" with the aforementioned filters (the %s gets replaced with your query).
Best Answer
Per default, Google gives you 4 autocomplete suggestions:
You can tweak your settings so that you'll get 10 suggestions. Go to Google search settings at https://www.google.com/preferences
For Google Instant predictions make sure Never Show Instant Results is ticked. Make sure to click the save settings button at the bottom of the page.
Now, try searching again. You should now get 10 suggestions: