There were a number of sites out there that did this via Yahoo Pipes – such as noReplies
Now that it appears that Yahoo Pipes is banned from accessing Twitter data, are there any other options?
I'd like to be able to link to my Twitter feed without @ replies – both as a clickable link, and ideally an RSS feed
Best Answer
So there is not native support for this request but it can be achieved with the help of some plugins and since you were already talking about Yahoo Pipes I am sure this will not be overly intimidating.
The plugin is called TweetFilter and is a "Twitter Filter for Firefox, Chrome, Opera and IE 8+"
One of the called out features is
a full list of the features and capabilities is here http://userscripts.org/scripts/show/49905
install instruction vary by browser view them all here http://tweetfilter.netne.net/
on a side note i use this plugin myself and its pretty awesome.