SPI Interfacing using Serial Port or USB

If you just want to do some experiments, then take a look at the Bus Pirate, it speaks tons of serial protocols at one end and USB on the other.

It looks like the keyboard and mouse example on the arduino site already has a method for reading the serial port.

/*
  KeyboardAndMouseControl

 Controls the mouse from five pushbuttons on an Arduino Leonardo or Micro.

 Hardware:
 * 5 pushbuttons attached to D2, D3, D4, D5, D6


 The mouse movement is always relative. This sketch reads 
 four pushbuttons, and uses them to set the movement of the mouse.

 WARNING:  When you use the Mouse.move() command, the Arduino takes
 over your mouse!  Make sure you have control before you use the mouse commands.

 created 15 Mar 2012
 modified 27 Mar 2012
 by Tom Igoe

 this code is in the public domain

 */

// set pin numbers for the five buttons:
const int upButton = 2;     
const int downButton = 3;        
const int leftButton = 4;
const int rightButton = 5;
const int mouseButton = 6;

void setup() { // initialize the buttons' inputs:
  pinMode(upButton, INPUT);       
  pinMode(downButton, INPUT);       
  pinMode(leftButton, INPUT);       
  pinMode(rightButton, INPUT);       
  pinMode(mouseButton, INPUT);

  Serial.begin(9600);
  // initialize mouse control:
  Mouse.begin();
  Keyboard.begin();
}

void loop() {

right here:

  // use serial input to control the mouse:
  if (Serial.available() > 0) {
    char inChar = Serial.read();

    switch (inChar) {   
    case 'u':
      // move mouse up
      Mouse.move(0, -40);
      break; 
    case 'd':
      // move mouse down
      Mouse.move(0, 40);
      break;
    case 'l':
      // move mouse left
      Mouse.move(-40, 0);
      break;
    case 'r':
      // move mouse right
      Mouse.move(40, 0);
      break;
    case 'm':
      // perform mouse left click
      Mouse.click(MOUSE_LEFT);
      break;
    }
  }

  // use the pushbuttons to control the keyboard:
  if (digitalRead(upButton) == HIGH) {
    Keyboard.write('u'); 
  }
  if (digitalRead(downButton) == HIGH) {
    Keyboard.write('d'); 
  }
  if (digitalRead(leftButton) == HIGH) {
    Keyboard.write('l'); 
  }
  if (digitalRead(rightButton) == HIGH) {
    Keyboard.write('r'); 
  }
  if (digitalRead(mouseButton) == HIGH) {
    Keyboard.write('m'); 
  }

}

If you can read the serial port, it seems like you can write to it too. I don't have a leonardo board to test this out myself, but inside of the loop() function you should be able to add something like

Serial.print("hello world");

and verify this while the Mouse and Keyboard are running too.