Gmail – Reply to Mailman List from Digest

Not automatically you can't.

You can set up a very generic filter that should capture most of the legit mailing lists that you're subscribed to.

Create a filter with the following:

• Has the words: unsubscribe
• Apply the label: lists

This will deal with most of the mailing lists since they should all include instructions, if not a link itself, to unsubscribe.

This should also cover those instances where the mailer addresses the To: field of the email directly to you and which might be a little tricky when filtering for to:me.

This answer assumes that all of the automated emails are sent from the same address.

I'm not sure how you've created your filter, but try filtering by the from: field only. If the automated sender's address is always something like no-reply@domain.com then set up your filter to filter on:

from: no-reply@domain.com

This will make sure all automated email will hit the filter. Then, when someone else replies to that address, the new sender's email will be different from the one listed in the filter, and allow it to hit the inbox as normal.