Electronic – Ultra low noise charge sensitive preamplifier

Looks like you are thinking many good thoughts and I can't say any of your points are counterproductive when coupled with careful layout.

As for other techniques, maybe it's worth taking a look at the bigger picture. Here are some ideas for that.

• When using 24 bit resolution (that is a LOT of resolution) for bio signals, you are often really using this for common mode/DC offset where the real signal resolution is only maybe 5-8 bits. There are other ways of achieving both high common mode rejection (instrumentation/differential amplifiers) and DC offset (Right-Leg-Drive) etc.

• Bio signals are often very low frequency, so low-pass filtering at the inputs can reduce the noise pickup.

• The very high impedance nature of typical bio signals results in very low currents. This makes the cable sensitive to noise. If you can shorten the cable, use shielded cables or bring the impedance down (by using an active electrode instead of a passive electrode), that can improve the situation.

As a final note: Think about where you want the return currents to run. That is the key to low voltage/low current design. Make sure you are not sharing the signals return current path with any other currents.

This going to be another controversial question, so let me paraphrase and occasionally quote from a source (textbook) that I find credible, EMC and the Printed Circuit Board by Mark Montrose. First, let's intro the usual terminology:

• safety ground = a ground that is connected by a low-impedance path to earth
• signal voltage (referencing) ground, e.g. ground plane on a PCB

Now a potentially shocking quote (p. 249):

Connection of the two ground methods may be unsuitable for a particular application and may exacerbate EMC problems. [...] Common misconceptions exist regarding grounding. Most analysts believe that ground is a current return path that a good ground reduces circuit noise. This belief causes many to assume that we can sink noisy RF current into the earth, generally through a building's main grounding structure. This valid if we are discussion safety grounding, not signal voltage reference. Although an RF return path is mandatory, it need not be at ground potential. Free space is not at ground potential.

(Emphasis mine).

So having established that (if it needed to be said), what about connecting a PCB (or in case of a multi-board device, several PCBs') ground to the metal case/chassis even if the latter is not connected to the earth/safety ground? (You could have a Faraday cage housed in a plastic enclosure for example.)

First we need to get something else cleared: if you have a multi-board system, single-point grounding (aka "holy" ground, no kidding) is suitable when the speed of signals/components is 1 Mhz or less, usually found in audio circuits, mains power systems, etc. For higher operating frequencies, e.g. a computer, multi-point grounding is used. For mixed frequencies both are combined in a hybrid grounding technique as shown below (figure from Montrose's book):

And here's basically why you want multi-point grounding for high-frequency systems, which in Montrose's book (p. 274) is explained in the context of a system with daughterboards (e.g. your typical desktop computer):

RF fields generated from a PCB [...] will couple to a metallic structure. As a result, RF eddy currents will develop in the structure and will circulate within the unit creating a field distribution. This field distribution may couple to other circuits [...] These [eddy] currents are coupled to the card cage through distributive transfer impedances and then through attempts to close the loop by coupling back to the backplane. If the common-mode reference impedance between the backplane and the card cage is not significantly lower than the distributive "driving source" (of the eddy currents) an RF voltage will be developed between the backplane and the card cage. [...] Simply put, the common-mode spectral potential between the backplane and card cage must be shorted out. This may take the form of frequently connecting the backplane ground plane to the card cage (chassis) at regular intervals around the perimeter of the backplane.

If you wondered why your desktop computer motherboard has electrical connections through all the screws that fasten it to the (metallic) case, that's why they're there.

N.B.: Joffe and Lock's Grounds for Grounding gives pretty much the same explanation in their section titled "Purpose of Stitching PCB Return Planes to Chassis", so I think the experts agree on this.